CI001

Cinnamic aldehyde



FormulaMI NumberCAS NumberC.I.Number
C9H8O2298104-55-2


MI: Merck Index Number
CAS: Chemical Abstract Service Registry Number
C.I.: Chemical Index Number


Background

Cinnamic aldehyde is a naturally occuring fragrance with the strong odor of cinnamon. It is found in cinnamon leaves, cinnamon bark, and the essential oils of hyacinth, myrrh, Bulgarian rose, patchouli, and other plants.
Cinnamic aldehyde is used as a fragrance in cosmetics and over-the-counter drugs as well as a flavoring agent in beverages, chewing gum, mouthwashes, and toothpaste.
Oral symptoms from toothpaste containing cinnamic aldehyde include sore mouth, dermatitis of the lips and perioral skin, swelling of the tongue, and mouth ulceration.
The International Fragrance Association recommends that cinnamic aldehyde be used with an equal proportion by weight of eugenol or d-limonene to prevent sensitization. This process is known as quenching.


Beschreibung (ger)

Zimtaldehyd, eine gelblich-ölige Flüssigkeit, ist wesentlicher Bestandteil von Stärkungsmitteln, Seifen, Detergentien und als geschmackliche Komponente in Zahnpasten, Süssigkeiten, Soft-Drinks und Konditorwaren enthalten, sowie in einigen Gewürzen.
Zimtverbindungen werden kosmetischen Präparaten (z.B. Sonnenschutz), Lebensmitteln, Haushalts- und Industrieprodukten zur Maskierung von unangenehmen Gerüchen zugesetzt.




Synonyms

2-Propenal-3-phenyl
3-Phenyl-2-propenal
Cinnamal (CTFA adopted name)
Cinnamaldehyde
Cinnamic aldehyde
Phenylacrolein


Uses

Balsam of Tolu and Balsam of Peru
Cinnamon, Ceylon, and Cassia oil
Foods ‹ cola, chocolate, ice cream, chewing gums
Fragranced household products such as deodorizers, detergents, and soaps
Perfumes
Plants ‹ hyacinth, etc.
Spices
Toothpaste
Lippenstift
Hustenbonbons
Zahnpasta
Hyazinthen und Narzissen
Backwaren
Gewürze
Seifen- und Reinigungsmittel
Kaugummi
Tabak
Mundwasser
Speiseeis
Süßigkeiten
als Aromastoff und in synthetischen Aromazusätzen
Alkoholische Getränke (Wermuth, Getränke mit Pfefferminzgeschmack)
Erfrischungsgetränke (Cola, Getränke mit Pfefferminzgeschmack


Cross-Reactions

Cinnamic acid
Cinnamic alcohol
Cinnamon oil
Perubalsma
Benzoetinktur
Patchouliöl
Cassiaöl
Lavendelöl


Unusual Reactions

Depigmentation
Non immunologic Contact urticaria
Photoallergy
Bei mir führt es zu anschwellen der Nebenhöhlen. Manchmal habe ich 24h nach Genuss des Lebensmittels mit dem Allergen Kopfschmerzen.


References

1. Calnan, C.D., Cinnamon dermatitis from an ointment. Contact Dermatitis, 1976. 2(3): p. 167-70.
2. Drake, T.E. and H.I. Maibach, Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Archives of Dermatology, 1976. 112(2): p. 202-3.
3. Fisher, A.A. and A. Dooms-Goossens, The effect of perfume "ageing" on the allergenicity of individual perfume ingredients. Contact Dermatitis, 1976. 2(3): p. 155-9.
4. Kirton, V., Contact urticaria and cinnamic aldehyde. Contact Dermatitis, 1978. 4(6): p. 374-5.
5. Romaguera, C. and F. Grimalt, Sensitization to cinnamic aldehyde in toothpaste. Contact Dermatitis, 1978. 4(6): p. 377-8.
6. Mathias, C.G., R.R. Chappler, and H.I. Maibach, Contact urticaria from cinnamic aldehyde. Archives of Dermatology, 1980. 116(1): p. 74-6.
7. Fergurson, J. and S. Sharma, Cinnamic aldehyde test concentrations [letter]. Contact Dermatitis, 1984. 10(3): p. 191-2.
8. Guin, J.D., et al., The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. Journal of the American Academy of Dermatology, 1984. 10(1): p. 45-51.
9. Malten, K.E., et al., Reactions in selected patients to 22 fragrance materials. Contact Dermatitis, 1984. 11(1): p. 1-10.
10. Maibach, H.I., Cheilitis: occult allergy to cinnamic aldehyde. Contact Dermatitis, 1986. 15(2): p. 106-7.
11. Nethercott, J.R., et al., Contact dermatitis due to cinnamic aldehyde induced in a deodorant manufacturing process. Contact Dermatitis, 1983. 9(3): p. 241-2.
12. Storrs, F.J., et al., Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. Journal of the American Academy of Dermatology, 1989. 20(6): p. 1038-45.
13. Weibel, H. and J. Hansen, Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro. Contact Dermatitis, 1989. 20(3): p. 167-72.
14. Speight, E.L. and C.M. Lawrence, Cinnamic aldehyde 2% pet. is irritant on patch testing. Contact Dermatitis, 1990. 23(5): p. 379-80.
15. Meding, B., Skin symptoms among workers in a spice factory. Contact Dermatitis, 1993. 29(4): p. 202-5.
16. Helton, J. and F. Storrs, The burning mouth syndrome: lack of a role for contact urticaria and contact dermatitis. Journal of the American Academy of Dermatology, 1994. 31(2 Pt 1): p. 201-5.
17. Seite-Bellezza, D., F. el Sayed, and J. Bazex, Contact urticaria from cinnamic aldehyde and benzaldehyde in a confectioner. Contact Dermatitis, 1994. 31(4): p. 272-3.
18. Johansen, J.D. and T. Menne, The fragrance mix and its constituents: a 14-year material. Contact Dermatitis, 1995. 32(1): p. 18-23.
19. Manzur, F., F. el Sayed, and J. Bazex, Contact allergy to cinnamic aldehyde and cinnamic alcohol in Oleophytal. Contact Dermatitis, 1995. 32(1): p. 55.


Most of this information originates from 

Trey Truett, MD
truettap@ctrvax.vanderbilt.edu.