FormulaMI NumberCAS NumberC.I.Number

MI: Merck Index Number
CAS: Chemical Abstract Service Registry Number
C.I.: Chemical Index Number


Isoeugenol is a fragrance and spice with the odor of cloves. It is found in the oils of clove, ylang-ylang, tuberose, and jonquil. It is manufactured by the isomerization of eugenol. The International Fragrance Research Association recommends that isoeugenol be used at no more than a 1% concentration in fragrance compounds. It is an approved flavoring agent for foods.

Beschreibung (ger)

Isoeugenol, eine farblose-weiße Flüssigkeit, wird als wesentlicher Bestandteil von Ylang-Ylang-Öl und Muskatnußöl in der Parfümerie verwendet, sowie in aromatisierten Teemischungen und Gewürzen.


2-Methoxy-4-(1-propenyl) phenol
4 -Propenylguaiacol
Isoeugenol acetate
Isoeugenol methyl ether


Cosmetics (clove and carnation scent)
Dental materials
Food flavor
Dental materials
Over-the-counter medicines
Production of vanillin flavor



Unusual Reactions


1. Maurer, T., et al., Predictive evaluation in animals of the contact allergenic potential of medically important substances. II. Comparison of different methods of cutaneous sensitization with "weak" allergens. Contact Dermatitis, 1979. 5(1): p. 1-10.
2. de Groot, A.C., et al., Patch tests with fragrance materials and preservatives. Contact Dermatitis, 1985. 12(2): p. 87-92.
3. Roberts, D.W., B.F. Goodwin, and D. Basketter, Methyl groups as antigenic determinants in skin sensitisation. Contact Dermatitis, 1988. 18(4): p. 219-25.
4. Roesyanto-Mahadi, I.D., et al., Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis, 1990. 22(4): p. 212-7.
5. Barratt, M.D. and D.A. Basketter, Possible origin of the skin sensitization potential of isoeugenol and related compounds. (I). Preliminary studies of potential reaction mechanisms. Contact Dermatitis, 1992. 27(2): p. 98-104.
6. de Groot, A.C., et al., Frequency of false-negative reactions to the fragrance mix. Contact Dermatitis, 1993. 28(3): p. 139-40.
7. Garrigue, J.L., et al., Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers. Contact Dermatitis, 1994. 30(4): p. 231-7.

This information originates from 

Trey Truett, MD